Scientists wake up to causes of sleep disruption in Alzheimer’s disease | University of Cambridge

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via Scientists wake up to causes of sleep disruption in Alzheimer’s disease | University of Cambridge.

New research using fruit flies with Alzheimer’s protein finds that the disease doesn’t stop the biological clock ticking, but detaches it from the sleep-wake cycle that it usually regulates. Findings could lead to more effective ways to improve sleep patterns in those with Alzheimer’s. Being awake at night and dozing during the day can be a distressing early symptom of Alzheimer’s disease, but how the disease disrupts our biological clocks to cause these symptoms has remained elusive. Now, scientists from Cambridge have discovered that in fruit flies with Alzheimer’s the biological clock is still ticking but has become uncoupled from the sleep-wake cycle it usually regulates. The findings – published in Disease Models & Mechanisms – could help develop more effective ways to improve sleep patterns in people with the disease.

We have shown in flies with Alzheimer’s that the clock is still ticking but being ignored by other parts of the brain -Damian Crowther

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