Pekovic-Vaughan (2014): Body clocks, chronic lung diseases linked, new research suggests

March 17, 2014
Manchester University
The body clock’s natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases. “This research is the first to show that a functioning clock in the lung is essential to maintain the protective tissue function against oxidative stress and fibrotic challenges. We envisage a scenario whereby chronic rhythm disruption (e.g., during aging or shift work) may compromise the temporal coordination of the antioxidant pathway, contributing to human disease,” authors explain.

V. Pekovic-Vaughan, J. Gibbs, H. Yoshitane, N. Yang, D. Pathiranage, B. Guo, A. Sagami, K. Taguchi, D. Bechtold, A. Loudon, M. Yamamoto, J. Chan, G. T. J. van der Horst, Y. Fukada, Q.-J. Meng. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes & Development, 2014; 28 (6): 548 DOI: 10.1101/gad.237081.113

via Body clocks, chronic lung diseases linked, new research suggests — ScienceDaily.


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