Pekovic-Vaughan (2014): Body clocks, chronic lung diseases linked, new research suggests

March 17, 2014
Source:
Manchester University
Summary:
The body clock’s natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases. “This research is the first to show that a functioning clock in the lung is essential to maintain the protective tissue function against oxidative stress and fibrotic challenges. We envisage a scenario whereby chronic rhythm disruption (e.g., during aging or shift work) may compromise the temporal coordination of the antioxidant pathway, contributing to human disease,” authors explain.

V. Pekovic-Vaughan, J. Gibbs, H. Yoshitane, N. Yang, D. Pathiranage, B. Guo, A. Sagami, K. Taguchi, D. Bechtold, A. Loudon, M. Yamamoto, J. Chan, G. T. J. van der Horst, Y. Fukada, Q.-J. Meng. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes & Development, 2014; 28 (6): 548 DOI: 10.1101/gad.237081.113

via Body clocks, chronic lung diseases linked, new research suggests — ScienceDaily.

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