The consequences of traumatic brain injury (TBI) are sizable in both human and economic terms. In the USA alone, about 1.7 million new injuries happen annually, making TBI the leading cause of death and disability in people younger than 35 years of age. Survivors usually exhibit lifelong disabilities involving both motor and cognitive domains, leading to an estimated annual cost of $76.5 billion in direct medical services and loss of productivity in the USA. This issue has received even more intense scrutiny in the popular media with respect to sports-related concussions where there is a proposed link between having suffered multiple injuries, regardless of severity, with later neurodegeneration. At present, there is a dearth of evidence to either support or undermine the role of sports concussions in the later development of neurodegenerative processes, much less the influence of those brain injuries on the normal aging process.