O’Callaghan, Roig, Mongrain (2016)

Cell adhesion molecules and sleep, Neuroscience Research

pdf: ocallaghan-et-al-2016-review

Cell adhesion molecules (CAMs) play essential roles in the central nervous system, where some families are involved in synaptic development and function. These synaptic adhesion molecules (SAMs) areinvolved in the regulation of synaptic plasticity, and the formation of neuronal networks. Recent findingsfrom studies examining the consequences of sleep loss suggest that these molecules are candidates to actin sleep regulation. This review highlights the experimental data that lead to the identification of SAMsas potential sleep regulators, and discusses results supporting that specific SAMs are involved in differ-ent aspects of sleep regulation. Further, some potential mechanisms by which SAMs may act to regulatesleep are outlined, and the proposition that these molecules may serve as molecular machinery in thetwo sleep regulatory processes, the circadian and homeostatic components, is presented. Together, thedata argue that SAMs regulate the neuronal plasticity that underlies sleep and wakefulness.

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