Sleep regulation of the distribution of cortical firing rates

Source: Sleep regulation of the distribution of cortical firing rates

pdf: Levenstein-2017-Sleep regulation of the distri

Sleep is thought to mediate both mnemonic and homeostatic
functions. However, the mechanism by which this brain state
can simultaneously implement the ‘selective’ plasticity needed
to consolidate novel memory traces and the ‘general’ plasticity
necessary to maintain a well-functioning neuronal system is
unclear. Recent findings show that both of these functions
differentially affect neurons based on their intrinsic firing rate, a
ubiquitous neuronal heterogeneity. Furthermore, they are both
implemented by the NREM slow oscillation, which also
distinguishes neurons based on firing rate during sequential
activity at the DOWN – UP transition. These findings suggest a
mechanism by which spiking activity during the slow oscillation
acts to maintain network statistics that promote a skewed
distribution of neuronal firing rates, and perturbation of that
activity by hippocampal replay acts to integrate new memory
traces into the existing cortical network.


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