Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons | Nature CommunicationsPosted: March 16, 2019
Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular function of sleep is unknown, and there is no conserved molecular marker to define sleep across phylogeny. Time-lapse imaging of chromosomal markers in single cells of live zebrafish revealed that sleep increases chromosome dynamics in individual neurons but not in two other cell types. Manipulation of sleep, chromosome dynamics, neuronal activity, and DNA double-strand breaks (DSBs) showed that chromosome dynamics are low and the number of DSBs accumulates during wakefulness. In turn, sleep increases chromosome dynamics, which are necessary to reduce the amount of DSBs. These results establish chromosome dynamics as a potential marker to define single sleeping cells, and propose that the restorative function of sleep is nuclear maintenance.
Recherche de doctorat de Claudia Picard-Deland
Marquis LP, Julien SH, Baril AA, Blanchette-Carrière C, Paquette T, Carr M, Soucy JP, Montplaisir J, Nielsen T.
J Clin Sleep Med. 2019 Feb 4. pii: jc-18-00539. [Epub ahead of print]
What are the determinants of children’s sleep behavior? A systematic review of longitudinal studies – ScienceDirectPosted: February 2, 2019
Tore Nielsen discusses the results of their study (Nielsen & Powell, 2015) on food and dreams in an interview with Lost and Found’s Jonathon Green of the Australian Broadcasting Corporation (26 Jan 2019).
original paper (pdf): nielsen-2015-dreams of the rarebit fiend_ food