Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons | Nature Communications

Source: Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons | Nature Communications

Abstract

Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular function of sleep is unknown, and there is no conserved molecular marker to define sleep across phylogeny. Time-lapse imaging of chromosomal markers in single cells of live zebrafish revealed that sleep increases chromosome dynamics in individual neurons but not in two other cell types. Manipulation of sleep, chromosome dynamics, neuronal activity, and DNA double-strand breaks (DSBs) showed that chromosome dynamics are low and the number of DSBs accumulates during wakefulness. In turn, sleep increases chromosome dynamics, which are necessary to reduce the amount of DSBs. These results establish chromosome dynamics as a potential marker to define single sleeping cells, and propose that the restorative function of sleep is nuclear maintenance.

Advertisements

J’observe l’effet d’une réactivation sonore durant le sommeil | UdeMNouvelles

Recherche de doctorat de Claudia Picard-Deland

Source: J’observe l’effet d’une réactivation sonore durant le sommeil | UdeMNouvelles


A Meaningful Step Toward Understanding the Cause and Impact of Nightmares

Source: JCSM – A Meaningful Step Toward Understanding the Cause and Impact of Nightmares

Commentary on:

Nightmare Severity Is Inversely Related to Frontal Brain Activity During Waking State Picture Viewing.

Marquis LP, Julien SH, Baril AA, Blanchette-Carrière C, Paquette T, Carr M, Soucy JP, Montplaisir J, Nielsen T.

J Clin Sleep Med. 2019 Feb 4. pii: jc-18-00539. [Epub ahead of print]


The Scary Science Behind the Sleep Paralysis in “Haunting of Hill House” | Sleepopolis

Source: The Scary Science Behind the Sleep Paralysis in “Haunting of Hill House” | Sleepopolis


What are the determinants of children’s sleep behavior? A systematic review of longitudinal studies – ScienceDirect

https://www.sciencedirect.com/science/article/pii/S1087079218300637

Tore


What works for jetlag? A systematic review of non-pharmacological interventions – ScienceDirect

https://www.sciencedirect.com/science/article/pii/S1087079218300029

Tore


Food and dreams: Tore Nielsen interview with ABC radio

Tore Nielsen discusses the results of their study (Nielsen & Powell, 2015) on food and dreams in an interview with Lost and Found’s Jonathon Green of the Australian Broadcasting Corporation (26 Jan 2019).

interview: https://www.abc.net.au/radionational/programs/blueprintforliving/features/the-last-half-hour/lost-and-found:-dreams/10743840

original paper (pdf): nielsen-2015-dreams of the rarebit fiend_ food